Abundant expression of IFN-gamma-inducible protein 10 (IP-10) was observed on macrophages and in T cells in perimysial infiltrates of dermatomyositis (DM), and strong chemokine (C-X-C motif) receptor (CXCR)3 expression was observed on the majority of T cells in DM. This suggests that the T helper (Th)1-mediated immunity in general, and the CXCR3/IP-10 interaction in particular, is important in the immunopathogenesis of DM. The study of infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with DM, confirmed the importance of Th1 chemokines. Type I Interferon chemokines, and overall IP-10, are tightly linked to active disease and are correlated with the clinical score in juvenile DM, thus could be helpful in monitoring disease activity and guiding treatment.
Dermatomyositis and chemokines
Elia G.
2015-01-01
Abstract
Abundant expression of IFN-gamma-inducible protein 10 (IP-10) was observed on macrophages and in T cells in perimysial infiltrates of dermatomyositis (DM), and strong chemokine (C-X-C motif) receptor (CXCR)3 expression was observed on the majority of T cells in DM. This suggests that the T helper (Th)1-mediated immunity in general, and the CXCR3/IP-10 interaction in particular, is important in the immunopathogenesis of DM. The study of infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with DM, confirmed the importance of Th1 chemokines. Type I Interferon chemokines, and overall IP-10, are tightly linked to active disease and are correlated with the clinical score in juvenile DM, thus could be helpful in monitoring disease activity and guiding treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
