In light of the persistent donor scarcity, it has been advocated to shift the current region-based allocation model for liver transplantation (OLT) to an interregional one, so as to allow sicker patients on the wait list to obtain timely transplantations. Being convinced that tackling the challenge of organ donor scarcity requires appropriate measures, we have suggested some initiatives to be taken at different levels. First, definition of the real need for OLT, since it is largely unknown to transplant physicians and still represents the starting line for any initiative in the field. Second, we recommend creation of liver transplant care processes organized around the concept of smooth, seamless, and prompt referral of liver disease patients. Third, we suggest continued efforts in the field of deceased donation, so as to reduce the chasm between organ donation and demand and limit the persistent variability among regions. Fourth, we favor patient mobility, so as to expand the opportunity for transplantation for sicker patients. Finally, we seek to improve the efficiency of interregional coordination by prompt referral of extended criteria donors, sicker patients, or patients with rare diseases, so as to expand the opportunity for better donor-to-recipient matching at a national level.