Aim: We retrospectively evaluated the effect of dabrafenib/trametinib combination in patients with BRAF-mutated non-small-cell lung cancer (NSCLC) treated in a single center from 2017 to 2022. Patients: The response and safety data of 42 patients (27 treated in first-line and 15 as second/subsequent lines) were analyzed. Results: The objective response was 73.8%, with no differences between patients undergoing first- or second-line. A longer, statistically significant median progression-free survival (PFS) was observed in patients receiving the combination in first-line vs those in the second/subsequent lines (19.9 months [95% CI: 19.7–20] vs 13.1 months [95% CI: 8.6–17.6], respectively; p = 0.012). The median overall survival (OS) was 29.9 months (95% CI: 14.1–45.7) for patients treated with the combination in first-line and 22.4 months (95% CI: 14.6–30.2) for those treated in subsequent lines. The combination was well tolerated Conclusion: We confirm the efficacy of dabrafenib/trametinib in BRAF-V600-mutated NSCLC.
Dabrafenib-trametinib in BRAF V600-mutated non-small-cell lung cancer: a single center real world experience
Sbrana, Andrea;Petrini, Iacopo;Massa, Valentina;Carrozzi, Laura;
2024-01-01
Abstract
Aim: We retrospectively evaluated the effect of dabrafenib/trametinib combination in patients with BRAF-mutated non-small-cell lung cancer (NSCLC) treated in a single center from 2017 to 2022. Patients: The response and safety data of 42 patients (27 treated in first-line and 15 as second/subsequent lines) were analyzed. Results: The objective response was 73.8%, with no differences between patients undergoing first- or second-line. A longer, statistically significant median progression-free survival (PFS) was observed in patients receiving the combination in first-line vs those in the second/subsequent lines (19.9 months [95% CI: 19.7–20] vs 13.1 months [95% CI: 8.6–17.6], respectively; p = 0.012). The median overall survival (OS) was 29.9 months (95% CI: 14.1–45.7) for patients treated with the combination in first-line and 22.4 months (95% CI: 14.6–30.2) for those treated in subsequent lines. The combination was well tolerated Conclusion: We confirm the efficacy of dabrafenib/trametinib in BRAF-V600-mutated NSCLC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
