Artificial intelligence to predict cancer risk, are we there yet? A comprehensive review across cancer types

Cancer remains the second leading cause of death worldwide, representing a substantial challenge to global health. Although traditional risk prediction models have played a crucial role in epidemiology of several cancer types, they have limitations especially in the ability to process complex and multidimensional data. In contrast, artificial intelligence (AI) approaches represent a promising solution to overcome this limitation. AI techniques have the potential to identify complex patterns and relationships in data that traditional methods might overlook, making them especially useful for handling large and heterogeneous datasets analysed in cancer research. This review first examines the current state of the art of AI techniques, highlighting their differences and suitability for various data types. Then, offers a comprehensive analysis of the literature, focusing on the application of AI approaches in nineteen cancer types (bladder cancer, breast cancer, cervical cancer, colorectal cancer, endometrial cancer, esophageal cancer, gastric cancer, gynaecological cancers, head and neck cancer, haematological cancers, kidney cancer, liver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, thyroid cancer and overall cancer), evaluating the models, metrics, and exposure variables used. Finally, the review discusses the application of AI in the clinical practice, along with an assessment of its potential limitations and future directions.