Two 10-minute openings of the mouth obtained with a spring device called mandibular extension applied at 10-minute intervals (2-ME treatment) induce a hypotensive effect in Spontaneously Hypertensive Rats (SHRs), producing a vasodilation previously observed in cortical parietal pial vascular districts. Herein, transcriptional analyses were performed to investigate a possible role of Galectin-1 (Gal-1) in the 2-ME treatment-induced hypotensive effects in the pial vascular district of the parietal cortex, and in an extracerebral observational point such as the thoracic aorta. Our results show that, with respect to controls, 120 minutes after 2-ME treatment, Gal-1 expression was significantly increased in the parietal pial vascular district and doubled in the thoracic aorta. GAL-1 levels determinations showed no differences in both the parietal pial vascular district and the thoracic aorta. Present data suggest that in our experimental model of hypertension, 2 ME treatment induced a modulation of gene expression for Gal-1 in vascular districts indicating an involvement of GAL-1 in driving the hypotensive effects.
Involvement of galectin-1 in the prolonged hypotensive effect induced by mandibular extension in spontaneously hypertensive rats
Giuseppe Federighi
Methodology
;Dominga LapiWriting – Review & Editing
;Rossana ScuriConceptualization
2025-01-01
Abstract
Two 10-minute openings of the mouth obtained with a spring device called mandibular extension applied at 10-minute intervals (2-ME treatment) induce a hypotensive effect in Spontaneously Hypertensive Rats (SHRs), producing a vasodilation previously observed in cortical parietal pial vascular districts. Herein, transcriptional analyses were performed to investigate a possible role of Galectin-1 (Gal-1) in the 2-ME treatment-induced hypotensive effects in the pial vascular district of the parietal cortex, and in an extracerebral observational point such as the thoracic aorta. Our results show that, with respect to controls, 120 minutes after 2-ME treatment, Gal-1 expression was significantly increased in the parietal pial vascular district and doubled in the thoracic aorta. GAL-1 levels determinations showed no differences in both the parietal pial vascular district and the thoracic aorta. Present data suggest that in our experimental model of hypertension, 2 ME treatment induced a modulation of gene expression for Gal-1 in vascular districts indicating an involvement of GAL-1 in driving the hypotensive effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
