Two new polyketide-derived pigments, named rufoolivacins B (2), and D (4), with a 4',10-coupled aryl linkage between polysubstituted 1-naphthol and 1,4- or 1,2-anthraquinone, together with nine known metabolites including rufoolivacins A (1) and C (3), have been isolated from the fruiting bodies of the Chinese toadstool Cortinarius rufo-olivaceus (basidiomycetes). Their structures were characterized on the basis of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HSQC, and HMBC). The axial chirality of 1 and 2 was assigned through analysis of their CD spectra and ZINDO and TDDFT calculations. Compounds 3 and 4 were found to be unusual natural products incorporating an ortho-anthraquinone chromophore. All the metabolites were shown to be toxic toward the brine shrimp.
|Autori:||GAO J-M; QIN J-C; PESCITELLI G; DI PIETRO S; MAA Y-T; ZHANG A-L|
|Titolo:||Structure and absolute configuration of toxic polyketide pigments from the fruiting bodies of the fungus Cortinarius rufo-olivaceus|
|Anno del prodotto:||2010|
|Digital Object Identifier (DOI):||10.1039/C002773A|
|Appare nelle tipologie:||1.1 Articolo in rivista|