The ability to predict the in vivo performance of multiblock-copolymer-based biomaterials is crucial for their applicability in the biomedical field. In this work, XPS analysis of PCL-PEG copolymers was carried out, as well as morphological and wettability evaluations by SEM and CA measurements, respectively. XPS analysis on films equilibrated in PBS demonstrated a further enrichment in the PEG component on the surface. Copolymer films obtained by casting using different solvents showed a dependence in segregation according to the solvent employed. Cell adhesion tests demonstrated the importance of copolymer segregation and rearrangement in a wet environment, with a dependence of these phenomena on the copolymer molecular weight.
|Autori:||COMETA S; CHIELLINI F; BARTOLOZZI I; CHIELLINI E; DE GIGLIO E; SABBATINI L|
|Titolo:||Surface segregation assessment in poly(ε-caprolactone)-poly(ethylene glycol) multiblock copolymer films|
|Anno del prodotto:||2010|
|Digital Object Identifier (DOI):||10.1002/mabi.200900284|
|Appare nelle tipologie:||1.1 Articolo in rivista|