Background: Type 2 diabetic patients (T2DM) are characterized by endothelial dysfunction. Aim: The aim of this study is to evaluate the effect of a nutritional and dietary counseling on BP control and endothelial dysfunction in T2DM. Methods: Nineteen T2DM patients (age 61±5 years, 4 females) were provided of a by a 2-day 24 hour dietary recall at 1, 3, 6, 9 and 12 months. Blood pressure, endothelium-dependent and independent (sublingual glycerol trinitrate, GTN, 25 mg) vasodilation were assessed at baseline and after 12 months. Twenty age and gender matched healthy subjects were recruited as controls. Results: At baseline T2DM had significantly (p < 0.01) lower FMD (4.3±1.9%) and FMD/GTN ratio (0.61±0.15) as compared to controls (6.9±2.1% and 0.91±0.22, respectively). Response to GTN was similar in T2DM (7.8±2.4%) and controls (7.6±3.0%). After 12 months, there was a significant (p < 0.01) reduction in systolic BP (from 145±17 to 133±8 mmHg) and a not significant reduction in diastolic BP (from 85±12 to 78±9 mmHg, p = 0.06), HbA1c (from 7.7±17 to 7.1±0.8%, p = 0.18) and plasma folate (from 6.1±8.4 to 11.4±8.5 mg/ml, p < 0.001). FMD (5.9±2.9%) and FMD/GTN ratio (0.84±0.61), but not response to GTN (7.4±1.7%) were also significantly (p < 0.05) improved. However, the improvement in FMD and FMD/GTN ratio was not related to changes in BP, metabolic control, plasma folate concentration or pharmacological treatment, but to sodium excretion reduction exclusively (r = 0.51, p < 0.005). Conclusions: A long term dietary counseling have positive effect on T2DM patients resulting in a significant better BP control and an improvement of endothelial dysfunction

TYPE 2 DIABETES: BLOOD PRESSURE CONTROL AND ENDOTHELIAL FUNTION ARE INFLUENCED BY NUTRITIONAL EDUCATIONAL PROGRAM

GIAMPIETRO, OTTAVIO;MATTEUCCI, ELENA
2010-01-01

Abstract

Background: Type 2 diabetic patients (T2DM) are characterized by endothelial dysfunction. Aim: The aim of this study is to evaluate the effect of a nutritional and dietary counseling on BP control and endothelial dysfunction in T2DM. Methods: Nineteen T2DM patients (age 61±5 years, 4 females) were provided of a by a 2-day 24 hour dietary recall at 1, 3, 6, 9 and 12 months. Blood pressure, endothelium-dependent and independent (sublingual glycerol trinitrate, GTN, 25 mg) vasodilation were assessed at baseline and after 12 months. Twenty age and gender matched healthy subjects were recruited as controls. Results: At baseline T2DM had significantly (p < 0.01) lower FMD (4.3±1.9%) and FMD/GTN ratio (0.61±0.15) as compared to controls (6.9±2.1% and 0.91±0.22, respectively). Response to GTN was similar in T2DM (7.8±2.4%) and controls (7.6±3.0%). After 12 months, there was a significant (p < 0.01) reduction in systolic BP (from 145±17 to 133±8 mmHg) and a not significant reduction in diastolic BP (from 85±12 to 78±9 mmHg, p = 0.06), HbA1c (from 7.7±17 to 7.1±0.8%, p = 0.18) and plasma folate (from 6.1±8.4 to 11.4±8.5 mg/ml, p < 0.001). FMD (5.9±2.9%) and FMD/GTN ratio (0.84±0.61), but not response to GTN (7.4±1.7%) were also significantly (p < 0.05) improved. However, the improvement in FMD and FMD/GTN ratio was not related to changes in BP, metabolic control, plasma folate concentration or pharmacological treatment, but to sodium excretion reduction exclusively (r = 0.51, p < 0.005). Conclusions: A long term dietary counseling have positive effect on T2DM patients resulting in a significant better BP control and an improvement of endothelial dysfunction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/138226
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