Introduction - Canine epitheliotropic cutaneous lymphoma, also named mycosis fungoides, has been described as an uncommon cutaneous lymphoma of T-cell origin, which is histologically characterized by the epitheliotropism of neoplastic T-lymphocytes. Two variants have been reported in man, based upon clinical and histopathological features: classical mycosis fungoides and Sezary syndrome. The disease in dogs is clinically classified as cutaneous nodular form, exfoliative erythroderma, mucocutaneous form, and oral form. Aim of the study - The aim is to point out the most interesting clinical and histopathological findings for the diagnosis, also carrying out a comparison with the human species. Material and methods - We report the cases of 20 dogs, diagnosed with epitheliotropic cutaneous lymphoma. Medical records of these animals were reviewed for rilevant data on signalment, anamnesis, clinical examination and histopathologic diagnosis. Results - All the clinical variants described by Scott in veterinary medicine were present alone or in combination: exfoliative erythroderma (75% dogs), mucocutaneous form (65% dogs), cutaneous nodular form (55% dogs), and oral form (25% dogs). On the basis of histological features, the most represented variant was pagetoid reticulosis (14/20 dogs, 70%). Sezary syndrome could not be found. Discussion - The clinical and histopathological features that were observed reflected those previously reported in the published literature, and showed interesting findings to be compared with the homologous human neoplasia.
Cutaneous epitheliotropic lymphoma: clinico-pathological features in 20 dogs
CORAZZA, MICHELE;ABRAMO, FRANCESCA
2010-01-01
Abstract
Introduction - Canine epitheliotropic cutaneous lymphoma, also named mycosis fungoides, has been described as an uncommon cutaneous lymphoma of T-cell origin, which is histologically characterized by the epitheliotropism of neoplastic T-lymphocytes. Two variants have been reported in man, based upon clinical and histopathological features: classical mycosis fungoides and Sezary syndrome. The disease in dogs is clinically classified as cutaneous nodular form, exfoliative erythroderma, mucocutaneous form, and oral form. Aim of the study - The aim is to point out the most interesting clinical and histopathological findings for the diagnosis, also carrying out a comparison with the human species. Material and methods - We report the cases of 20 dogs, diagnosed with epitheliotropic cutaneous lymphoma. Medical records of these animals were reviewed for rilevant data on signalment, anamnesis, clinical examination and histopathologic diagnosis. Results - All the clinical variants described by Scott in veterinary medicine were present alone or in combination: exfoliative erythroderma (75% dogs), mucocutaneous form (65% dogs), cutaneous nodular form (55% dogs), and oral form (25% dogs). On the basis of histological features, the most represented variant was pagetoid reticulosis (14/20 dogs, 70%). Sezary syndrome could not be found. Discussion - The clinical and histopathological features that were observed reflected those previously reported in the published literature, and showed interesting findings to be compared with the homologous human neoplasia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.