A total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.
Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives
ROSSI, RENZO;CARPITA, ADRIANO;
1989-01-01
Abstract
A total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.File in questo prodotto:
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