CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishA total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.
| Autori interni: | ||
| Autori: | HUDSON J B; GRAHAM E A; MIKI N; TOWERS G. H. N; ROSSI R; CARPITA A; NERI D | |
| Titolo: | Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives | |
| Anno del prodotto: | 1989 | |
| Digital Object Identifier (DOI): | 10.1016/0045-6535(89)90080-5 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2022