A total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.
|Autori:||HUDSON J B; GRAHAM E A; MIKI N; TOWERS G. H. N; ROSSI R; CARPITA A; NERI D|
|Titolo:||Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives|
|Anno del prodotto:||1989|
|Digital Object Identifier (DOI):||10.1016/0045-6535(89)90080-5|
|Appare nelle tipologie:||1.1 Articolo in rivista|