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EnglishA total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.
| Autori interni: | |
| Autori: | HUDSON J B; GRAHAM E A; MIKI N; TOWERS G. H. N; ROSSI R; CARPITA A; NERI D |
| Titolo: | Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives |
| Anno del prodotto: | 1989 |
| Digital Object Identifier (DOI): | 10.1016/0045-6535(89)90080-5 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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