Several derivatives of 2,2':5',2''-terthiophene, 1a, and a structural analogue of this natural phototoxin, i.e. 5-[4-(1,2-methylenedioxy)phenyl]-2,2'-bithiophene, 2, have been conveniently synthesized on a medium scale using a general approach which involves palladium-catalyzed carbon-carbon bond forming reactions between (hetero)aryl halides and heteroaryl organometallics such as Grignard reagents, organozinc and organotin compounds. These 2,2':5',2''-terthiophene derivatives, which include some naturally-occurring compounds, have been characterized by EIMS spectrometry, H-1 and C-13 NMR spectroscopy as well as by absorption and fluorescence measurements. Four of these phototoxins exhibit considerable antibiotic and antiviral properties in the presence of UVA light and are cytotoxic against the P 815 mouse mastocytoma cell line.
|Autori interni:||ROSSI, RENZO|
|Autori:||ROSSI R; CARPITA A; CIOFALO; M; HOUBEN; J. L|
|Titolo:||Synthesis and characterization of 2,2':5',2"-terthiophene derivatives of possible therapeutic use|
|Anno del prodotto:||1990|
|Appare nelle tipologie:||1.1 Articolo in rivista|