Background and aims: Normotensive non-diabetic relatives of type 1 diabetics (T1D) have an abnormal blood pressure response to exercise testing that is associated with indices of metabolic syndrome and oxidative damage. We compared the pattern of 24-h ambulatory blood pressure monitoring (ABPM), ambulatory arterial stiffness index (AASI), indices of cardiovascular autonomic function, clinical and biochemical parameters, and oxidative biomarker between T1D patients, their siblings and controls. Methods: ABPM was undertaken in 25 controls, 20 T1D and 20 siblings. In addition to laboratory examination (including homeostasis model assessment of insulin sensitivity) and clinical testing of autonomic function, we measured the rate of oxidant-induced erythrocyte electron transfer to extracellular ferricyanide (RBC vfcy). Results: Systolic blood pressure (SBP) midline-estimating statistic of rhythm and pulse pressure were higher in T1D and correlated positively with diabetes duration and RBC vfcy; autonomic dysfunction was associated with diastolic BP ecphasia and increased AASI. Siblings had higher BMI, lower insulin sensitivity, larger SBP amplitude, and higher AASI than controls. Daytime SBP was positively independently associated with BMI and RBC vfcy. Among non-diabetic people, there was a significant correlation between AASI and fasting plasma glucose. Conclusions: Siblings of T1D exhibited a cluster of metabolic abnormalities associated with consensual perturbations in vascular variability (abnormal diurnal profiles of SBP and abnormal dynamic relationship between SBP and DBP over 24 h as described by AASI). Moreover, our findings support, in a clinical setting, the proposed role of transplasma membrane electron transport systems in vascular pathobiology
CIRCADIAN BLOOD PRESSURE VARIABILITY, AMBULATORY ARTERIAL STIFFNESS INDEX AND ERYTHROCYTE ELECTRON TRANSFER IN SIBLINGS OF TYPE 1 DIABETES FAMILIES
MATTEUCCI, ELENA;GIAMPIETRO, OTTAVIO
2010-01-01
Abstract
Background and aims: Normotensive non-diabetic relatives of type 1 diabetics (T1D) have an abnormal blood pressure response to exercise testing that is associated with indices of metabolic syndrome and oxidative damage. We compared the pattern of 24-h ambulatory blood pressure monitoring (ABPM), ambulatory arterial stiffness index (AASI), indices of cardiovascular autonomic function, clinical and biochemical parameters, and oxidative biomarker between T1D patients, their siblings and controls. Methods: ABPM was undertaken in 25 controls, 20 T1D and 20 siblings. In addition to laboratory examination (including homeostasis model assessment of insulin sensitivity) and clinical testing of autonomic function, we measured the rate of oxidant-induced erythrocyte electron transfer to extracellular ferricyanide (RBC vfcy). Results: Systolic blood pressure (SBP) midline-estimating statistic of rhythm and pulse pressure were higher in T1D and correlated positively with diabetes duration and RBC vfcy; autonomic dysfunction was associated with diastolic BP ecphasia and increased AASI. Siblings had higher BMI, lower insulin sensitivity, larger SBP amplitude, and higher AASI than controls. Daytime SBP was positively independently associated with BMI and RBC vfcy. Among non-diabetic people, there was a significant correlation between AASI and fasting plasma glucose. Conclusions: Siblings of T1D exhibited a cluster of metabolic abnormalities associated with consensual perturbations in vascular variability (abnormal diurnal profiles of SBP and abnormal dynamic relationship between SBP and DBP over 24 h as described by AASI). Moreover, our findings support, in a clinical setting, the proposed role of transplasma membrane electron transport systems in vascular pathobiologyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
