A regioselective introduction of a methoxycarbonyl methyl group at the C2 position of unsubstituted pyridine has been accomplished with catalytic amounts of copper(II) triflate in mild reaction conditions. The N-acetyl-1,2-dihydropyridyl acetic acid methyl ester obtained is a valuable building block for the synthesis of new polyfunctionalized piperidine derivatives bearing unconventional substitution patterns
Copper-Catalyzed Perkin Acyl-Mannich Reaction of AceticAnhydride with Pyridine: Expeditious Entry to Unconventional Piperidines
PINESCHI, MAURO
2011-01-01
Abstract
A regioselective introduction of a methoxycarbonyl methyl group at the C2 position of unsubstituted pyridine has been accomplished with catalytic amounts of copper(II) triflate in mild reaction conditions. The N-acetyl-1,2-dihydropyridyl acetic acid methyl ester obtained is a valuable building block for the synthesis of new polyfunctionalized piperidine derivatives bearing unconventional substitution patternsFile in questo prodotto:
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