The authors describe the synthesis of several N-(indol-3-ylglyoxylyl)methionine derivatives. The target compounds were prepared starting from substituted indoleglyoxylyl chlorides and methionine ethyl ester. Some of them were tested for their gastric anti-secretory activity. Among these compounds, the N-(5-chloroindol-3-ylglyoxylyl)methionine Ve was the most active, being quite comparable to cimetidine.
|Autori:||A. Da Settimo; G. Primofiore; Marini A; P.L. Ferrarini; J.S. Franzone; R. Cirillo; C. Reboani.|
|Titolo:||N-(Indol-3-ylglyoxylyl)methionine derivatives: preparation and gastric anti-secretory activity.|
|Anno del prodotto:||1988|
|Digital Object Identifier (DOI):||10.1016/0223-5234(88)90162-6|
|Appare nelle tipologie:||1.1 Articolo in rivista|