This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(epsilon-caprolactone) (*PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wet-spinning, were optimized. Stemming from a previous research activity on electrospinning of *PCL, *PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres' morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into *PCL fibrous mats. Fibres loaded with either CD or CD-HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition.

Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite

PUPPI, DARIO;PIRAS, ANNA MARIA;CHIELLINI, FEDERICA;CHIELLINI, EMO;
2011-01-01

Abstract

This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(epsilon-caprolactone) (*PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wet-spinning, were optimized. Stemming from a previous research activity on electrospinning of *PCL, *PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres' morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into *PCL fibrous mats. Fibres loaded with either CD or CD-HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition.
2011
Puppi, Dario; Piras, ANNA MARIA; Chiellini, Federica; Chiellini, Emo; Martins, A; LEONOR I., B; Neves, N; Reis, R.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/150666
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 84
  • ???jsp.display-item.citation.isi??? 73
social impact