Background. The early diagnosis of AS, essential to modify the natural course of disease and to reduce disability (1,2) is often missed and markedly delayed (3). Objective. To investigate the influence of demographic, social and clinical features at onset on diagnostic delay (DD) in an Italian cohort of AS patients. Methods. In 135 AS patients (45 female and 90 male, 36,5±10,2 years old at diagnosis and 28,3±10,2 at onset) with disease onset between 1950 and 2008, were investigated: the time between onset and diagnosis, demographic (age at onset of the disease <16 or >16 years old, sex) and social character- istics (level of instruction, manual work or not), HLA 27 (pre- sent/absent), first symptoms at onset (peripheral arthritis/enthesitis/spondiloarthritis/uveitis), familiarity (for AS, psoriasis and psoriatic arthritis [PsA], inflammatory bowel disease [IBD]) Results. The DD since onset of symptoms to diagnosis was 9±8 years (range 1-47). In table I. demographic, social and clinical features of AS patients are shown in Table 1. DD was significantly different between genders (higher in male p<0,002) and types of clinical onset (higher in arthritis, enthe- sitis and uveitis than in axial symptoms p>0,03), but was not correlated with age, social factors and HLA B27 positivity. Conclusions. In our Italian cohort, DD was significantly lower in axial onset and higher in male, but was not influenced by age, social factors and HLAB27.
Diagnostic delay in italian patients with ankylosing spondylitis (AS)
RIENTE, LUCREZIA;BOMBARDIERI, STEFANO;
2011-01-01
Abstract
Background. The early diagnosis of AS, essential to modify the natural course of disease and to reduce disability (1,2) is often missed and markedly delayed (3). Objective. To investigate the influence of demographic, social and clinical features at onset on diagnostic delay (DD) in an Italian cohort of AS patients. Methods. In 135 AS patients (45 female and 90 male, 36,5±10,2 years old at diagnosis and 28,3±10,2 at onset) with disease onset between 1950 and 2008, were investigated: the time between onset and diagnosis, demographic (age at onset of the disease <16 or >16 years old, sex) and social character- istics (level of instruction, manual work or not), HLA 27 (pre- sent/absent), first symptoms at onset (peripheral arthritis/enthesitis/spondiloarthritis/uveitis), familiarity (for AS, psoriasis and psoriatic arthritis [PsA], inflammatory bowel disease [IBD]) Results. The DD since onset of symptoms to diagnosis was 9±8 years (range 1-47). In table I. demographic, social and clinical features of AS patients are shown in Table 1. DD was significantly different between genders (higher in male p<0,002) and types of clinical onset (higher in arthritis, enthe- sitis and uveitis than in axial symptoms p>0,03), but was not correlated with age, social factors and HLA B27 positivity. Conclusions. In our Italian cohort, DD was significantly lower in axial onset and higher in male, but was not influenced by age, social factors and HLAB27.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
