The structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones A-D (1-4), four new α-pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis ( 1H, 13C, 1H- 1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 1-4 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities.

Phomopsinones A-D: Four New Pyrenocines from Endophytic Fungus Phomopsis sp.

PESCITELLI, GENNARO;DI PIETRO, SEBASTIANO
2012

Abstract

The structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones A-D (1-4), four new α-pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis ( 1H, 13C, 1H- 1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 1-4 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities.
Hussain, H; Krohn, K; Ahmed, I; Draeger, S; Schulz, B; Di Pietro, S; Pescitelli, Gennaro; DI PIETRO, Sebastiano
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/153275
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