The structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones A-D (1-4), four new α-pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis ( 1H, 13C, 1H- 1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 1-4 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities.
|Autori:||Hussain H; Krohn K; Ahmed I; Draeger S; Schulz B; Di Pietro S; Pescitelli G|
|Titolo:||Phomopsinones A-D: Four New Pyrenocines from Endophytic Fungus Phomopsis sp.|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1002/ejoc.201101788|
|Appare nelle tipologie:||1.1 Articolo in rivista|