The objective of the study was to evaluate the pharmacokinetic profile of the antipsychotic drug sulpiride (SL) after single intravenous (IV) and intramuscular (IM) injection (1 mg/kg b.w.) in six mares, according to a 2x2 Latin square study design. Plasma concentrations of SL were determined using a validated HPLC-FL method. No side-effect was shown after drug administration. The IV and IM administrations showed similar profiles with a negligible difference in the absorption phase. The bioavailability was higher in the IM group. The drug at 1 mg/kg dose (clinically used dosage regimen) should not accumulate with a repeated once a day administration regimen. Unfortunately, no report on the minimal effective concentration in horses is reported so far. Further studies are necessary to establish the optimal dose rate in this animal species.
PHARMACOKINETIC OF SULPIRIDE FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONS IN MARES
GIORGI, MARIO;CAMILLO, FRANCESCO;PANZANI, DUCCIO
2012-01-01
Abstract
The objective of the study was to evaluate the pharmacokinetic profile of the antipsychotic drug sulpiride (SL) after single intravenous (IV) and intramuscular (IM) injection (1 mg/kg b.w.) in six mares, according to a 2x2 Latin square study design. Plasma concentrations of SL were determined using a validated HPLC-FL method. No side-effect was shown after drug administration. The IV and IM administrations showed similar profiles with a negligible difference in the absorption phase. The bioavailability was higher in the IM group. The drug at 1 mg/kg dose (clinically used dosage regimen) should not accumulate with a repeated once a day administration regimen. Unfortunately, no report on the minimal effective concentration in horses is reported so far. Further studies are necessary to establish the optimal dose rate in this animal species.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
