Secoscabronine M (1) is a hemiacetal cyathane diterpenoid that was isolated from the fruiting bodies of the basidiomycete Sarcodon scabrosus (Fr.) Karst. Compound 1 possesses a novel structure with a bond cleavage between C-3 and C-4. The structure of the new compound was elucidated by means of spectroscopic methods, including two-dimensional nuclear magnetic resonance experiments. The absolute configuration of 1 was established by analysis of circular dichroism spectroscopy and also by employing time-dependent density functional theory calculations. In addition, compound 1 was confirmed to be an equilibrium mixture of two epimers (15S and 15R) at position C-15 in polar solvents by one-dimensional nuclear magnetic resonance analysis.
|Autori:||Shi X-W; Zhang A-L; Pescitelli G; Gao J-M|
|Titolo:||Secoscabronine M, a novel diterpenoid from the Chinese bitter mushroom Sarcodon scabrosus|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1002/chir.22031|
|Appare nelle tipologie:||1.1 Articolo in rivista|