Some 3-amino- and 3-hydroxy-8-halosubstituted 6H-indolo[2,3-b] [1,8]naphthyridines were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. All prepared compounds were more active than the corresponding 8-unsubstituted derivatives. Moreover, among these compounds the 8-chloroindolonaphthyridines were clearly the most potent.
|Autori:||Da Settimo A; Primofiore G; Ferrarini PL; Mori C; Martini C; Pennacchi E; Lucacchini A.|
|Titolo:||Synthesis of new 6H-indolo[2,3-b] [1,8]naphthyridines and their specific inhibition of benzodiazepine receptor.|
|Anno del prodotto:||1986|
|Appare nelle tipologie:||1.1 Articolo in rivista|