Abstract PURPOSE: To evaluate the modifications of EEG activity during slow-wave sleep in patients with dementia compared with healthy elderly subjects, using spectral analysis and period-amplitude analysis. METHODS: Five patients with dementia and 5 elderly control subjects underwent night polysomnographic recordings. For each of the first three nonrapid eye movement-rapid eye movement sleep cycles, a well-defined slow-wave sleep portion was chosen. The delta frequency band (0.4-3.6 Hz) in these portions was analyzed with both spectral analysis and period-amplitude analysis. RESULTS: Spectral analysis showed an increase in the delta band power in the dementia group, with a decrease across the night observed only in the control group. For the dementia group, period-amplitude analysis showed a decrease in well-defined delta waves of frequency lower than 1.6 Hz and an increase in such waves of frequency higher than 2 Hz, in incidence and amplitude. CONCLUSIONS: Our study showed (1) a loss of the dynamics of delta band power across the night sleep, in dementia, and (2) a different distribution of delta waves during slow-wave sleep in dementia compared with control subjects. This kind of computer-based analysis can highlight the presence of a pathologic delta activity during slow-wave sleep in dementia and may support the hypothesis of a dynamic interaction between sleep alteration and cognitive decline.
BONANNI, ENRICA (Primo)
DI COSCIO, ELISA (Secondo)
|Autori:||Bonanni, Enrica; DI COSCIO, Elisa; Maestri, Michelangelo; Carnicelli, Luca; Tsekou, H; Economou, Nt; Paparrigoupolos, T; Bonakis, A; Papageorgiou, Sg; Vassipoulos, D; Soldatos, Cr; Murri, Luigi; Ktonas, P. Y.|
|Titolo:||Differences in EEG delta frequency characteristics and patterns in slow-wave sleep between dementia patients and controls: a pilot study.|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1097/WNP.0b013e318246b56d.|
|Appare nelle tipologie:||1.1 Articolo in rivista|