Live attenuated vaccines provide the most consistent protective immunity in experimental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naïve animals and appear to limit the spread of histological lesions to the contralateral joints.
|Autori:||Bertolotti L; Reina R; Mazzei M; Preziuso S; Camero M; Carrozza ML; Cavalli A; Juganaru M; Profiti M; De Meneghi D; Perona G; Renzoni G; Tursi M; Bertoni G; Rosati S.|
|Titolo:||Small ruminant lentivirus genotype B and E interaction: Evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain.|
|Anno del prodotto:||2013|
|Digital Object Identifier (DOI):||10.1016/j.vetmic.2012.12.004|
|Appare nelle tipologie:||1.1 Articolo in rivista|