A new azaphilone derivative, named fusarone (1), has been isolated from the ethyl acetate soluble extract of the fermentation broth of an endophytic fungus, Fusarium sp. LN-12, isolated from the leaves of Melia azedarach Linn. The structure of the new compound was established on the basis of extensive spectroscopic analysis, including 1D-NMR and 2D-NMR (1H-1H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. The absolute configurations of fusarone () and of a second related azaphilone were determined by means of electronic circular dichroism spectroscopy and optical rotation calculations. Chirality 24:621627, 2012. (c) 2012 Wiley Periodicals, Inc.
Absolute Configuration of Fusarone, a New Azaphilone from the Endophytic Fungus Fusarium sp Isolated from Melia azedarach, and of Related Azaphilones
PESCITELLI, GENNARO
2012-01-01
Abstract
A new azaphilone derivative, named fusarone (1), has been isolated from the ethyl acetate soluble extract of the fermentation broth of an endophytic fungus, Fusarium sp. LN-12, isolated from the leaves of Melia azedarach Linn. The structure of the new compound was established on the basis of extensive spectroscopic analysis, including 1D-NMR and 2D-NMR (1H-1H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. The absolute configurations of fusarone () and of a second related azaphilone were determined by means of electronic circular dichroism spectroscopy and optical rotation calculations. Chirality 24:621627, 2012. (c) 2012 Wiley Periodicals, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
