A 10-year-old spayed female domestic longhaired cat was referred for evaluation of thoracic limbs weakness and lameness. Muscular hypertrophy and firmness involved mainly proximal muscles, particularly the infraspinatus, supraspinatus, triceps and extensor carpi radialis of the right thoracic limb and semitendinosus, semimembranosus and gluteal muscles of the right pelvic limb with no neurological deficits. Moderate increase of creatine kinase activity was also revealed. Muscle biopsy showed myopathic features such as rounded atrophic and hypertrophic fibres, increased number of centrally located myofibre nuclei, scattered rimmed vacuoles, mild perimysial and endomysial fibrosis. Myofibre necrosis with phagocytosis were present in the gluteal muscle. By immunohistochemistry, absence of sarcolemmal caveolin-3 was observed in almost all muscle fibres and sarcoplasmic accumulation of the protein was observed in approximately 30% of myofibres. Since a normal expression of caveolin-3 was detected by immunoblotting, a protein mislocalization in the sarcoplasm due to an aberrant trafficking towards the sarcolemma was suspected. This case represents the first case of muscular dystrophy due to a caveolinopathy in animals.

Adult-onset muscular dystrophy in a cat associated with a presumptive alteration in trafficking of caveolin-3

SALVADORI, CLAUDIA;CANTILE, CARLO
2012-01-01

Abstract

A 10-year-old spayed female domestic longhaired cat was referred for evaluation of thoracic limbs weakness and lameness. Muscular hypertrophy and firmness involved mainly proximal muscles, particularly the infraspinatus, supraspinatus, triceps and extensor carpi radialis of the right thoracic limb and semitendinosus, semimembranosus and gluteal muscles of the right pelvic limb with no neurological deficits. Moderate increase of creatine kinase activity was also revealed. Muscle biopsy showed myopathic features such as rounded atrophic and hypertrophic fibres, increased number of centrally located myofibre nuclei, scattered rimmed vacuoles, mild perimysial and endomysial fibrosis. Myofibre necrosis with phagocytosis were present in the gluteal muscle. By immunohistochemistry, absence of sarcolemmal caveolin-3 was observed in almost all muscle fibres and sarcoplasmic accumulation of the protein was observed in approximately 30% of myofibres. Since a normal expression of caveolin-3 was detected by immunoblotting, a protein mislocalization in the sarcoplasm due to an aberrant trafficking towards the sarcolemma was suspected. This case represents the first case of muscular dystrophy due to a caveolinopathy in animals.
Salvadori, Claudia; Vattemi, G; Marini, M; Bocchese, E; Tomelleri, G; ELVIRA UTRILLA, A; Cantile, Carlo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/156589
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