Enrofloxacin (E)1, is the most commonly used antimicrobial in reptile medicine because of its excellent efficacy. However, few studies have been performed in this species. The aim of the present study was to evaluate the pharmacokinetics of E and its metabolite ciprofloxacin (C)2 in 21 yellow-bellied slider turtles (Trachemys scripta scripta). The animals were administered 10 mg/kg of E via intracoelomic injection. Blood was collected at scheduled times and analyzed using a validated HPLC fluorescence method. The turtles showed some indications of transient pain following administration. The pharmacokinetics of E and C were long lasting (196 and 168 h, respectively). This could be of concern where turtles are used for food (eg some eastern cultures) because of the drug residues. The administered dose seemed to be optimal from the clinical point of view because i) drug concentrations in blood were toxic for bacterial but not for the animal’s cells and ii) effective Cmax/MIC and AUC/MIC ratios were achieved. In conclusion, the dose of 10 mg/kg administered via intracoelomic injection in yellow-bellied slider turtles, appeared safe and able to provide optimal pharmacodynamic parameters.
BLOOD CONCENTRATION OF ENROFLOXACIN AND ITS METABOLITE CIPROFLOXACIN IN YELLOW-BELLIED SLIDER TURTLES (TRACHEMYS SCRIPTA SCRIPTA), AFTER A SINGLE INTRACOELOMIC INJECTION OF ENROFLOXACIN
GIORGI, MARIO;BRIGANTI, ANGELA
2013-01-01
Abstract
Enrofloxacin (E)1, is the most commonly used antimicrobial in reptile medicine because of its excellent efficacy. However, few studies have been performed in this species. The aim of the present study was to evaluate the pharmacokinetics of E and its metabolite ciprofloxacin (C)2 in 21 yellow-bellied slider turtles (Trachemys scripta scripta). The animals were administered 10 mg/kg of E via intracoelomic injection. Blood was collected at scheduled times and analyzed using a validated HPLC fluorescence method. The turtles showed some indications of transient pain following administration. The pharmacokinetics of E and C were long lasting (196 and 168 h, respectively). This could be of concern where turtles are used for food (eg some eastern cultures) because of the drug residues. The administered dose seemed to be optimal from the clinical point of view because i) drug concentrations in blood were toxic for bacterial but not for the animal’s cells and ii) effective Cmax/MIC and AUC/MIC ratios were achieved. In conclusion, the dose of 10 mg/kg administered via intracoelomic injection in yellow-bellied slider turtles, appeared safe and able to provide optimal pharmacodynamic parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
