In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.
|Autori:||Tascini C; Di Paolo A; Poletti R; Flammini S; Emdin M; Ciullo I; Tagliaferri E; Moter A; Menichetti F|
|Titolo:||Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis|
|Anno del prodotto:||2013|
|Digital Object Identifier (DOI):||10.1128/AAC.01608-12|
|Appare nelle tipologie:||1.1 Articolo in rivista|