X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D-3 or 1 alpha-hydroxyvitamin D-3 plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected patients usually show normal growth hormone (GH) secretion. in some poorly growing XLH patients, long-term GH treatment associated with conventional therapy improves linear growth. GH treatment also increases phosphate retention but th is effect is transient. Copyright (C) 2000 S. Karger AG, Basel.
Hypophosphataemic rickets
SAGGESE, GIUSEPPE;
2000-01-01
Abstract
X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D-3 or 1 alpha-hydroxyvitamin D-3 plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected patients usually show normal growth hormone (GH) secretion. in some poorly growing XLH patients, long-term GH treatment associated with conventional therapy improves linear growth. GH treatment also increases phosphate retention but th is effect is transient. Copyright (C) 2000 S. Karger AG, Basel.File in questo prodotto:
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