The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial, and microsomal enzymes (markers of peroxisome proliferation) in liver, gill, and kidney of sea bass following 2 weeks i.p. treatment have been studied, Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmitoyl-CoA oxidase, carnitine-palmitoyl-transferase, p-nitrophenylacetate hydrolase, and benzaldehyde and propionaldehyde dehydrogenase activities was not observed in any case. The clofibrate administration at the dose of 70 mg/kg induced in the liver the glutathione S-tranferase and reduced epoxide hydrolase activities. These results demonstrate that a marine fish species, such as sea bass, is rafractary to peroxisome proliferation. (C) 1999 Academic Press.
|Autori interni:||PRETTI, CARLO|
|Autori:||Pretti C; Novi S; Longo V; Gervasi PG|
|Titolo:||Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.1006/enrs.1998.3893|
|Appare nelle tipologie:||1.1 Articolo in rivista|