During the first month of postnatal life, the dendritic arborizations of cat retinal ganglion cells continue to develop and undergo a substantial remodeling. Mechanical and pharmacological interferences with the normal development induce, during this period of time, substantial modifications in ganglion cell morphology. Specifically, the degeneration of those neurons whose axons were severed by a neonatal retinal lesion leads to a zone depleted of ganglion cells. Neurons at the border of the depleted area develop an abnormal elongation of the dendritic trees toward the empty space. In the present paper, we report data showing that this dendritic reorganization can be prevented by blocking the electrical activity with repeated tetrodotoxin injections into the eye during the whole critical period. Our analysis was performed on neurons filled with horseradish peroxidase.
|Autori interni:||GARGINI, MARIA CLAUDIA|
|Autori:||S. DEPLANO; GARGINI M; S. BISTI|
|Titolo:||Electrical activity regulates dendritic reorganization in ganglion cells after neonatal retinal lesion in the cat|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.1002/(sic)1096-9861(19990308)405:2<262::aid-cne9>3.0.co;2-4|
|Appare nelle tipologie:||1.1 Articolo in rivista|