Exploration of the systemic disposition of macromols. in relation to their physicochem. properties, could be a strategy for designing targeting systems. This work deals with the investigation of the Vitamin D3 conformation in the phospholipid bilayer in order to define a possible preferred binding site at the C=O- or PO2-phospholipid moiety (structure-function studies) to be exploited into drug discovery efforts.
Determination of the cholecalciferol-lipid complex using a combination of comparative modelling and NMR spectroscopy
UCCELLO BARRETTA, GLORIA;BALZANO, FEDERICA;
2000-01-01
Abstract
Exploration of the systemic disposition of macromols. in relation to their physicochem. properties, could be a strategy for designing targeting systems. This work deals with the investigation of the Vitamin D3 conformation in the phospholipid bilayer in order to define a possible preferred binding site at the C=O- or PO2-phospholipid moiety (structure-function studies) to be exploited into drug discovery efforts.File in questo prodotto:
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