Analysis of the growth requirements of Epstein-Barr virus (EBV)-transformed B lymphocytes shows that interleukin 1 and thioredoxin, a disulfide reducing enzyme, are able to induce a marked increase in DNA synthesis in the early phases of in vitro culture. By contrast, interleukin 6 induces a steady increase in DNA synthesis comparable to that observed with crude conditioned supernatant. Furthermore, EBV-transformed B cells exhibit a density-dependent responsiveness to autocrine growth factors, thus suggesting that growth regulation of EBV-transformed B cells might result from the interplay between different self-stimulating soluble factors and from the competence of the cells to respond to autocrine growth factors.
|Autori:||GARZELLI C; BAZZICHI A; DAYAH AM; MANUNTA M; INCAPRERA M|
|Titolo:||DENSITY-DEPENDENT RESPONSIVENESS TO AUTOCRINE GROWTH-FACTORS OF EPSTEIN-BARR-VIRUS TRANSFORMED HUMAN LYMPHOCYTES-B|
|Anno del prodotto:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|