A new method for C2-aza-glycosylation with glycal donors has been developed. The method involves a novel process for nitrogen transfer to glycals that 1) employs thianthrene-5-oxide and triflic anhydride as a new reagent combination for glycal activation; and 2) effects, for the first time, a direct installation of the naturally occurring C2-N-acetylamino functionality onto glycal donors in conjunction with glycosidic coupling to various glycosyl acceptors in an overall one-pot procedure.
|Autori:||V. DI BUSSOLO; J. LIU; L.G. HUFFMAN; D.Y. GIN|
|Titolo:||Acetamidiglycosylation with Glycal Donors: A One-Pot Glycosidic Coupling with Direct Installation of the Natural C(2)-N-Acetylamino Functionality|
|Anno del prodotto:||2000|
|Digital Object Identifier (DOI):||10.1002/(SICI)1521-3773(20000103)39:1<204::AID-ANIE204>3.0.CO;2-Z|
|Appare nelle tipologie:||1.1 Articolo in rivista|