The precise function of the 5-HT receptors remains undefined, and progress toward this has been hampered by the lack of selective ligands. Direct interactions with the 5-HT1A receptor via selective ligands may have beneficial effects in a large no. of diseases including a no. of neuropsychiatric disorders. The findings regarding the conformational analyses for a small set of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivs. as high-affinity, selective 5-HT1A receptors are reported.
5-HT1A receptors mapping by conformational analysis (2D NOESY/MM) and "threewaymodelling" (HASL, CoMFA, PARM)
UCCELLO BARRETTA, GLORIA;BALZANO, FEDERICA
2000-01-01
Abstract
The precise function of the 5-HT receptors remains undefined, and progress toward this has been hampered by the lack of selective ligands. Direct interactions with the 5-HT1A receptor via selective ligands may have beneficial effects in a large no. of diseases including a no. of neuropsychiatric disorders. The findings regarding the conformational analyses for a small set of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivs. as high-affinity, selective 5-HT1A receptors are reported.File in questo prodotto:
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