This investigation deals with the preparation, in-vitro characterization and preliminary in-vivo evaluation of albumin microspheres containing piroxicam. The albumin piroxicam microspheres, designed for ocular administration, were prepared by a spray-drying technique. The morphological and dimensional characteristics of the particles were studied by scanning- electron microscopy and particle-size analysis. Their in-vitro release behaviour was investigated in pH 7-0 USP23 buffer by use of a flow-through apparatus. Piroxicam in the albumin microspheres dissolved more quickly in- vitro than did piroxicam powder. The pharmacokinetic profile of piroxicam in aqueous humour was investigated in albino rabbits. The albumin piroxicam microspheres resulted in greater bioavailability of piroxicam than commercial piroxicam eyedrops.
Albumin microspheres for ocular delivery of piroxicam
CHETONI, PATRIZIA;
2000-01-01
Abstract
This investigation deals with the preparation, in-vitro characterization and preliminary in-vivo evaluation of albumin microspheres containing piroxicam. The albumin piroxicam microspheres, designed for ocular administration, were prepared by a spray-drying technique. The morphological and dimensional characteristics of the particles were studied by scanning- electron microscopy and particle-size analysis. Their in-vitro release behaviour was investigated in pH 7-0 USP23 buffer by use of a flow-through apparatus. Piroxicam in the albumin microspheres dissolved more quickly in- vitro than did piroxicam powder. The pharmacokinetic profile of piroxicam in aqueous humour was investigated in albino rabbits. The albumin piroxicam microspheres resulted in greater bioavailability of piroxicam than commercial piroxicam eyedrops.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
