Purpose: to outline the incidence, presenting features, treatment response, and outcome of human immunodeficiency virus (HIV)-associated malignancies in infancy and childhood, together with the estimated risk of HIV-associated cancer in children born to mothers infected with HIV. Patients and Methods: The Italian Register for HN Infection in Children collected data by specific registration and follow-up forms. By March 1999, 5,060 children were recruited, including 4,889 with perinatal exposure to HIV-1. Overall, 1,331 infected children were enrolled onto the Register and classified according to current Centers for Disease Control criteria; of them, 1,163 were vertically infected (24% of those with perinatal exposure). Of these 1,163, 569 (49%) were considered to have been prospectively followed-up since they had been registered at birth or within the first 3 months of age. Results: Of the 1,331 children observed for a median time of 6.5 years, 35 developed 36 malignancies, four of which occurred in patients with blood-borne risk. For the 1,163 vertically infected children, the cumulative number of years of observation was 7,178 child-years and the cumulative incidence of HIV-associated tumors was 4. 18 per 1,000 children/yr (95% confidence interval [CI], 2.92 to 5.98). When only the 569 vertically infected children prospectively followed up since birth were considered, the cumulative number of years of observation was 2,803 child-years. In this group, 10 rumors were observed, with a cumulative incidence of HIV-associated tumors of 3.57 per 1,000 children per year (95% CI, 1.92 to 6.63). Conclusion: The risk of cancer was significantly higher but nor restricted to symptomatic and/or immune-compromised children. Cancer-directed treatment should be given promptly to these patients, who have ct fair chance to survive their tumor in view of potential highly aggressive antiretroviral therapy-associated improvement in survival and quality of life.
|Autori:||Author(s): Caselli; D; Klersy; C; de Martino; M; Gabiano; C; Galli; L; Tovo; PA; Aricò; M Group Author(s): Italian Register HIV Infect Children: Osimani; P; Di Bari; C; Larovere; D; Ruggeri; M; Masi; M; Specchia; F; Battisti; L; Duse; M; Crispino; P; Carrara; P; Pintor; C; Dedoni; M; Dessì; C; Loriano; D; Anastasio; E; Bezzi; T; De Luca; M; Farina; S; Vierucci; A; Bassetti; D; Pedemonte; P; Toscanini; F; Marazzi; MG; Tasso; L; Plebani; A; Salvini; F; Pinzani; R; Bricalli; D; Viganò; A; Sala; N; Zuccotti; GV; Riva; E; Giovannini; M; Liprieri; R; Conio; S; Ferraris; G; Cellini; C; Baraldi; C; Guarino; A; Bruzzese; E; Tarallo; L; Giaquinto; C; Giacomet; V; Rampon; O; Dalle Nogare; ER; Sanfilipp; A; Romano; A; Benaglia G; Dodi; I; Caselli; D; Maccabruni; A; Pacati; R; Consolini R; Legitimo A; et al|
|Titolo:||Human immunodeficiency virus-related cancer in children: Incidence and treatment outcome - Report of the Italian Register|
|Anno del prodotto:||2000|
|Appare nelle tipologie:||1.1 Articolo in rivista|