In mice repeated systemic injections of Pseudomonas aeruginosa viable cells were able to induce a specific delayed-type hypersensitivity, which was evaluated as increase both in footpad swelling and in the weight of popliteal lymph nodes, after a challenge in the footpad. Unfractionated spleen cells or T lymphocyte-enriched spleen cells from sensitized donors were able to specifically transfer the delayed-type hypersensitivity to syngeneic recipients but failed to protect them against a lethal challenge with P. aeruginosa. In contrast, serum or B lymphocyte and macrophage-enriched spleen cells from the same donors were capable of transferring protective immunity but failed to induce any delayed-type hypersensitivity reaction in the recipients. These results clearly show that in systemic P. aeruginosa infections a dissociation between delayed-type hypersensitivity and acquired cellular resistance occurs.
|Autori interni:||CAMPA, MARIO|
|Autori:||CAMPA M; TOCA L; LOMBARDI S; GARZELLI C; COLIZZI V; FALCONE G|
|Titolo:||CELL-MEDIATED-IMMUNITY AND DELAYED-TYPE HYPERSENSITIVITY IN PSEUDOMONAS AERUGINOSA-INFECTED MICE|
|Anno del prodotto:||1982|
|Digital Object Identifier (DOI):||10.1007/BF02298199|
|Appare nelle tipologie:||1.1 Articolo in rivista|