The skin penetration of roxithromycin was studied in 27 surgical patients treated with 300 mg orally followed by three oral doses of 150 mg 12-hourly. Peak plasma and skin concentrations of 7.9 ± 1.2 mg/l and 31.3 ± 3.7 mg/kg occurred 2.5 and 4 h after last dosing respectively. The plasma and skin half-lives were 7.7 and 6.0 h, and the mean plasma and skin area under the curve values were 64.3 mg/l.h and 155.3 mg/kg.h. Skin/plasma concentration ratios were 4.9 ± 0.5, 9.7 ± 1.2, 7.6 ± 0.8 and 5.9 ± 1.1, at 3, 4, 5 and 6 h after last dosing respectively. These results demonstrate that roxithromycin achieves high levels in human skin.
|Autori:||CAMPA M; ZOLFINO I; SENESI S; BERNARDINI N; DANESI R; DUCCI M; OLEGGINI M; DISTEFANO R; MOSCA F; LAZZARINI A; DEL TACCA M|
|Titolo:||THE PENETRATION OF ROXITHROMYCIN INTO HUMAN SKIN|
|Anno del prodotto:||1990|
|Digital Object Identifier (DOI):||10.1093/jac/26.1.87|
|Appare nelle tipologie:||1.1 Articolo in rivista|