In order to investigate the mechanism(s) by which Epstein-Barr virus (EBV) induces the outcome of autoantibodies during infectious mononucleosis (IM), a human IgM (k) monoclonal antibody to cytoskeletal filaments of epithelial cells has been prepared by EBV transformation of peripheral blood B lymphocytes obtained from a patient with IM. The antibody was also found to react with smooth muscle of frozen sections of human stomach tissue by immunofluorescence, and with the Epstein-Barr nuclear antigen (EBNA) by an enzyme-linked immunosorbent assay. These findings demonstrate at the clonal level the epitope homology between host's cell antigens and EBV-encoded nuclear antigen, which might have relevance in EBV-induced autoimmunity.
|Autori interni:||GARZELLI, CARLO|
|Autori:||GARZELLI C; PACCIARDI A; CARMIGNANI M; CONALDI G; BASOLO F; FALCONE G|
|Titolo:||A HUMAN MONOCLONAL AUTOANTIBODY ISOLATED FROM A PATIENT WITH INFECTIOUS-MONONUCLEOSIS REACTIVE WITH BOTH SELF ANTIGENS AND EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN (EBNA)|
|Anno del prodotto:||1989|
|Digital Object Identifier (DOI):||10.1016/0165-2478(89)90193-4|
|Appare nelle tipologie:||1.1 Articolo in rivista|