Some 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines were synthesized and tested for their ability to displace [3H]clonazepam or [3H]Ro 5-4864 from their specific binding on the central and peripheral benzodiazepine receptors. None of the tested compounds showed any activity as central binding inhibitors, while most of them were specific as peripheral binding inhibitors, although they were not very potent.

SYNTHESIS OF 1,5-DIARYL-3-METHYL-1H-PYRAZOLO[4,5-C]ISOQUINOLINES AND STUDIES OF BINDING TO SPECIFIC PERIPHERAL BENZODIAZEPINE BINDING-SITES

MARTINI, CLAUDIA;GIANNACCINI, GINO;LUCACCHINI, ANTONIO
1989-01-01

Abstract

Some 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines were synthesized and tested for their ability to displace [3H]clonazepam or [3H]Ro 5-4864 from their specific binding on the central and peripheral benzodiazepine receptors. None of the tested compounds showed any activity as central binding inhibitors, while most of them were specific as peripheral binding inhibitors, although they were not very potent.
1989
Cecchi, L; Colotta, V; Melani, F; Palazzino, G; Filacchioni, G; Martini, Claudia; Giannaccini, Gino; Lucacchini, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/173347
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