The authors investigated the possible correlations between the binding parameters, maximum binding capacity (B-max) and dissociation constant (K-d), of [H-3]-8 hydroxy-2-(di-N-propylamino)tetralin and [H-3]-imipramine in platelets of 13 healthy subjects. The in vitro pharmacological characterization was also carried out for a further comparison. The results, showing that the B-max values were significantly and positively correlated, together with the findings of the displacement studies, suggest that in human platelets, [H-3]-8 hydroxy-2-(di-N-propylamino)tetralin and [H-3]-imipramine bind to the same protein.
CORRELATION BETWEEN THE SITES LABELED BY [H-3]-8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN AND [H-3]-IMIPRAMINE IN HUMAN PLATELETS
ROSSI, ALESSANDRA;GIANNACCINI, GINO;MARTINI, CLAUDIA;LUCACCHINI, ANTONIO;
1995-01-01
Abstract
The authors investigated the possible correlations between the binding parameters, maximum binding capacity (B-max) and dissociation constant (K-d), of [H-3]-8 hydroxy-2-(di-N-propylamino)tetralin and [H-3]-imipramine in platelets of 13 healthy subjects. The in vitro pharmacological characterization was also carried out for a further comparison. The results, showing that the B-max values were significantly and positively correlated, together with the findings of the displacement studies, suggest that in human platelets, [H-3]-8 hydroxy-2-(di-N-propylamino)tetralin and [H-3]-imipramine bind to the same protein.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
