The present study investigates the effects of atriopeptin II on spontaneous phasic contractions of rabbit isolated ileum. Atriopeptin II caused a significant and concentration-dependent decrease in ileum motor activity. This effect was mimicked by 8-Br-cGMP and it was not affected by pretreatment with tetrodotoxin. Verapamil significantly decreased ileum contractions; however, in the presence of this calcium blocker, atriopeptin II further reduced ileal motility. These findings demonstrate that atriopeptin II depresses the motility of rabbit ileum through a cGMP-dependent mechanism and suggest that neither ileal neural networks nor extracellular calcium are involved in this effect.
Atrial natriuretic peptide inhibits the spontaneous contractions of isolated rabbit ileum / Blandizzi, Corrado; Agen, C; Natale, Gianfranco; DEL TACCA, Mario. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 44:7(1992), pp. 615-617.
|Autori:||Blandizzi, Corrado; Agen, C; Natale, Gianfranco; DEL TACCA, Mario|
|Titolo:||Atrial natriuretic peptide inhibits the spontaneous contractions of isolated rabbit ileum|
|Anno del prodotto:||1992|
|Digital Object Identifier (DOI):||10.1111/j.2042-7158.1992.tb05477.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|