A simple, efficient, anti-stereoselective, highly regioselective method is described for the synthesis of gamma-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous THF, in the presence of LiClO4.
SYNTHESIS OF GAMMA-HYDROXY KETONES BY LICLO4-CATALYZED ADDITION OF LITHIUM ENOLATES TO 1,2-EPOXIDES
CROTTI, PAOLO;FAVERO, LUCILLA;PINESCHI, MAURO
1991-01-01
Abstract
A simple, efficient, anti-stereoselective, highly regioselective method is described for the synthesis of gamma-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous THF, in the presence of LiClO4.File in questo prodotto:
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