Intracerebroventricular administration of CCK-8S was associated with a stimulation of gastric pepsinogen secretion from anaesthetized rats; similar effects were induced by CCK-8S given intravenously. The excitatory effect of intracerebroventricular CCK-8S was not modified by central injection of L-364,718 or L-365,260, whereas both these antagonists, given by intravenous route, prevented the pepsigogue action of parenteral CCK-8S. Intracerebroventricular or intravenous CCK-8S also increased basal acid secretion, this latter effect being prevented by parenteral L-365,260 but not L-364,718. It is suggested that centrally applied CCK-8S evokes pepsinogen secretion through the activation of peripheral CCK-A and CCK-B receptors.
|Autori:||BLANDIZZI C; NATALE G; CARIGNANI D; COLUCCI R; LAZZERI G; DEL TACCA M.|
|Titolo:||Central administration of cholecystokinin stimulates gastric pepsinogen secretion from anaesthetized rats.|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1016/0304-3940(95)11654-F|
|Appare nelle tipologie:||1.1 Articolo in rivista|