Twelve dogs naturally infected with Leishmania infantum were treated subcutaneously with aminosidine at a dose of 10 mg kg(-1) per day for four weeks, Antimonial compounds were used as reference drugs in twelve Leishmania-infected dogs. Eleven of the twelve dogs submitted to aminosidine therapy responded within 30 days. The treatment with the aminoglycoside antibiotic presented a marked decrease of anti-Leishmania antibody titres than the controls. Aminosidine also reduced urinary protein, serum IgG, and circulating immune complex concentrations. Side effects were observed only in a dog with pre-existent renal lesions, This study proved that aminosidine is an effective, tolerable and safe drug for the treatment of canine leishmaniasis and that it could be used as a suitable substitute for antimonial therapy. (C) 1997 Published by Elsevier Science B.V.
|Autori:||Poli A; Sozzi S; Guidi G; Bandinelli P; Mancianti F|
|Titolo:||Comparison of aminosidine (paromomycin) and sodium stibogluconate for treatment of canine leishmaniasis|
|Anno del prodotto:||1997|
|Digital Object Identifier (DOI):||10.1016/S0304-4017(97)00014-9|
|Appare nelle tipologie:||1.1 Articolo in rivista|