The effects of alpha 2-adrenoceptor ligands on electrically stimulated [3H]acetylcholine release from longitudinal muscle strips of guinea-pig ileum were examined. Xylazine or oxymetazoline reduced the release of [3H]acetylcholine in a concentration-dependent manner, both these actions being antagonized by idazoxan, CH 38083, or WB 4101. Prazosin, considered as an alpha 2B-adrenoceptor antagonist, failed to modify the inhibitory effects of xylazine or oxymetazoline. It is concluded that the alpha 2-adrenoceptors involved in the modulation of acetylcholine release from cholinergic axon terminals of guinea-pig ileum are of the alpha 2A subtype.
|Autori:||BLANDIZZI C; Doda M.; Tarkovacs G.; Del Tacca M.; Vizi E.S.|
|Titolo:||Functional evidence that acetylcholine release from Auerbach’s plexus of guinea-pig ileum is modulated by alpha-2A-adrenoceptor subtype|
|Anno del prodotto:||1991|
|Digital Object Identifier (DOI):||10.1016/0014-2999(91)90916-E|
|Appare nelle tipologie:||1.1 Articolo in rivista|