Knowledge of mitochondria bioenergetics and network behaviour is rapidly expanding. Mitochondrial ␣␣m can now be investigated not only in cultured cells but also in clinical settings using fluorescent probes and living whole blood cells. The phenomenon of heterogeneity in mitochondrial ␣␣m has been observed in several cell types. Mitochondrial depolarisation/hyperpolarisation should represent a molecular switch in T cell signalling pathways and could have a role in autoimmunity. The manuscript discusses the problematic interpretation of measured changes in peripheral leukocyte ␣␣m in human health disorders, with special attention to diabetes, taken into account that mitochondrial homeostasis reflects an intricate balance of many (not well known) factors.

Leukocyte Mitochondrial Membrane Potential in Type 1 Diabetes

MATTEUCCI, ELENA;GIAMPIETRO, OTTAVIO
2012-01-01

Abstract

Knowledge of mitochondria bioenergetics and network behaviour is rapidly expanding. Mitochondrial ␣␣m can now be investigated not only in cultured cells but also in clinical settings using fluorescent probes and living whole blood cells. The phenomenon of heterogeneity in mitochondrial ␣␣m has been observed in several cell types. Mitochondrial depolarisation/hyperpolarisation should represent a molecular switch in T cell signalling pathways and could have a role in autoimmunity. The manuscript discusses the problematic interpretation of measured changes in peripheral leukocyte ␣␣m in human health disorders, with special attention to diabetes, taken into account that mitochondrial homeostasis reflects an intricate balance of many (not well known) factors.
2012
Matteucci, Elena; Giampietro, Ottavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/175625
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