Knowledge of mitochondria bioenergetics and network behaviour is rapidly expanding. Mitochondrial ␣␣m can now be investigated not only in cultured cells but also in clinical settings using fluorescent probes and living whole blood cells. The phenomenon of heterogeneity in mitochondrial ␣␣m has been observed in several cell types. Mitochondrial depolarisation/hyperpolarisation should represent a molecular switch in T cell signalling pathways and could have a role in autoimmunity. The manuscript discusses the problematic interpretation of measured changes in peripheral leukocyte ␣␣m in human health disorders, with special attention to diabetes, taken into account that mitochondrial homeostasis reflects an intricate balance of many (not well known) factors.
Leukocyte Mitochondrial Membrane Potential in Type 1 Diabetes
MATTEUCCI, ELENA;GIAMPIETRO, OTTAVIO
2012-01-01
Abstract
Knowledge of mitochondria bioenergetics and network behaviour is rapidly expanding. Mitochondrial ␣␣m can now be investigated not only in cultured cells but also in clinical settings using fluorescent probes and living whole blood cells. The phenomenon of heterogeneity in mitochondrial ␣␣m has been observed in several cell types. Mitochondrial depolarisation/hyperpolarisation should represent a molecular switch in T cell signalling pathways and could have a role in autoimmunity. The manuscript discusses the problematic interpretation of measured changes in peripheral leukocyte ␣␣m in human health disorders, with special attention to diabetes, taken into account that mitochondrial homeostasis reflects an intricate balance of many (not well known) factors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.