The monosaccharide component (alpha and beta-anomer) of the E Ring of calicheamicin (I)(gamma 1) and esperamicin A(1) has been synthetized by an efficient and improved stereoselective procedure starting from methyl 2-deoxy-alpha- and beta-D-ribopyranoside. The synthetic procedure makes use, in each case, of a cyclic sulphate and of the regioselective ring opening of an intermediate activated aziridine. (C) 1997 Elsevier Science Ltd.
Improved stereoselective synthesis of both methyl alpha- and beta-glycosides corresponding to the amino sugar component of the E ring of calicheamicin (I)(gamma 1) and esperamicin A(1)
CROTTI, PAOLO;FAVERO, LUCILLA;PINESCHI, MAURO
1997-01-01
Abstract
The monosaccharide component (alpha and beta-anomer) of the E Ring of calicheamicin (I)(gamma 1) and esperamicin A(1) has been synthetized by an efficient and improved stereoselective procedure starting from methyl 2-deoxy-alpha- and beta-D-ribopyranoside. The synthetic procedure makes use, in each case, of a cyclic sulphate and of the regioselective ring opening of an intermediate activated aziridine. (C) 1997 Elsevier Science Ltd.File in questo prodotto:
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