NONIMMUNOLOGIC risk factors have been recognized of importance for the development of graft failure as the immunologic ones. Since Na+/H+ exchange restorates intracellular pH following ischemia-induced acidosis, it has been implied in ischemia-reperfusion injury. We tested the hypothesis suggesting that ischemia-reperfusion damage might be related to the activity of donor/ recipient Na+/H+ antiport that is engaged in (1) leukocyte inflammatory and migratory responses,3 (2) cell susceptibility to ischemic insult,’ and (3) rigenerative capacity of resilient cells.
Role of donor/recipient Na+/H+ antiport activity as a nonimmunologic predictor of kidney graft outcome.
MATTEUCCI, ELENA;MOSCA, FRANCO;GIAMPIETRO, OTTAVIO
1997-01-01
Abstract
NONIMMUNOLOGIC risk factors have been recognized of importance for the development of graft failure as the immunologic ones. Since Na+/H+ exchange restorates intracellular pH following ischemia-induced acidosis, it has been implied in ischemia-reperfusion injury. We tested the hypothesis suggesting that ischemia-reperfusion damage might be related to the activity of donor/ recipient Na+/H+ antiport that is engaged in (1) leukocyte inflammatory and migratory responses,3 (2) cell susceptibility to ischemic insult,’ and (3) rigenerative capacity of resilient cells.File in questo prodotto:
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