NONIMMUNOLOGIC risk factors have been recognized of importance for the development of graft failure as the immunologic ones. Since Na+/H+ exchange restorates intracellular pH following ischemia-induced acidosis, it has been implied in ischemia-reperfusion injury. We tested the hypothesis suggesting that ischemia-reperfusion damage might be related to the activity of donor/ recipient Na+/H+ antiport that is engaged in (1) leukocyte inflammatory and migratory responses,3 (2) cell susceptibility to ischemic insult,’ and (3) rigenerative capacity of resilient cells.
|Autori:||Matteucci E; Carmellini M; Bertoni C; Boldrini E; Cosi C; Mosca F; Giampietro O|
|Titolo:||Role of donor/recipient Na+/H+ antiport activity as a nonimmunologic predictor of kidney graft outcome.|
|Anno del prodotto:||1997|
|Appare nelle tipologie:||1.1 Articolo in rivista|