So far, vaccination experiments against feline immunodeficiency virus have used in vitro-grown virus to challenge the vaccinated hosts. In this study, cats were vaccinated with fixed feline immunodeficiency virus-infected cells and challenged with plasma obtained from cats infected with the homologous virus diluted to contain 10 cat 50% infectious doses. As judged by virus culture, PCRs, and serological analyses performed over an 18-month period after the challenge, all of the vaccinated cats were clearly protected. Interestingly, prior to challenge most vaccinees lacked antibodies capable of neutralizing a fresh isolate of the homologous virus.
|Autori interni:||PISTELLO, MAURO|
|Autori:||Matteucci D; Pistello M; Mazzetti P; Giannecchini S; DelMauro D; Zaccaro L; Bandecchi P; Tozzini F; Bendinelli M|
|Titolo:||Vaccination protects against in vivo grown feline immunodeficiency virus even in the absence of detectable neutralizing antibodies|
|Anno del prodotto:||1996|
|Appare nelle tipologie:||1.1 Articolo in rivista|