So far, vaccination experiments against feline immunodeficiency virus have used in vitro-grown virus to challenge the vaccinated hosts. In this study, cats were vaccinated with fixed feline immunodeficiency virus-infected cells and challenged with plasma obtained from cats infected with the homologous virus diluted to contain 10 cat 50% infectious doses. As judged by virus culture, PCRs, and serological analyses performed over an 18-month period after the challenge, all of the vaccinated cats were clearly protected. Interestingly, prior to challenge most vaccinees lacked antibodies capable of neutralizing a fresh isolate of the homologous virus.

Vaccination protects against in vivo grown feline immunodeficiency virus even in the absence of detectable neutralizing antibodies

PISTELLO, MAURO
Writing – Original Draft Preparation
;
BANDECCHI, PATRIZIA
Writing – Original Draft Preparation
;
1996

Abstract

So far, vaccination experiments against feline immunodeficiency virus have used in vitro-grown virus to challenge the vaccinated hosts. In this study, cats were vaccinated with fixed feline immunodeficiency virus-infected cells and challenged with plasma obtained from cats infected with the homologous virus diluted to contain 10 cat 50% infectious doses. As judged by virus culture, PCRs, and serological analyses performed over an 18-month period after the challenge, all of the vaccinated cats were clearly protected. Interestingly, prior to challenge most vaccinees lacked antibodies capable of neutralizing a fresh isolate of the homologous virus.
Matteucci, D; Pistello, Mauro; Mazzetti, P; Giannecchini, S; Delmauro, D; Zaccaro, L; Bandecchi, Patrizia; Tozzini, F; Bendinelli, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/175932
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