A number of 7-amino-2-dialkylaminoalkylpyrrolo[3,4-c]pyridin-1,3(2H)-dione derivatives were synthesized and their local anaesthetic activity was evaluated in vivo by corneal anaesthesia in rabbits. Only compounds 3, 9 and 14 showed any activity, albeit lower than that of the reference drug lidocaine.
Synthesis and local anaesthetic activity of some 7-amino-2-dialkylaminoalkylpyrrolo[3,4-c]pyridine derivatives
DA SETTIMO PASSETTI, FEDERICO;MARINI, ANNA MARIA;LA MOTTA, CONCETTINA;SIMORINI, FRANCESCA;
1996-01-01
Abstract
A number of 7-amino-2-dialkylaminoalkylpyrrolo[3,4-c]pyridin-1,3(2H)-dione derivatives were synthesized and their local anaesthetic activity was evaluated in vivo by corneal anaesthesia in rabbits. Only compounds 3, 9 and 14 showed any activity, albeit lower than that of the reference drug lidocaine.File in questo prodotto:
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